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How to Get Off Psychiatric Drugs Safely

Copyright Notice
Patent Pending

Forward

A Note From James Harper, Founder, The Road Back

Table of Contents

Part One

Chapter

1. The Road Back Basics

2. The Four Simple Steps

3. Suggested Nutritionals for The Road Back Program

4. Things You Need to Know

5. Things to Be Aware Of

6. General Pre-Tapering and Tapering Instructions

7. Daily Journal

8. Graph Your Success

9. Pre-Taper For: Benzodiazepines, Anti-Convulsants, Anti-Anxiety & Sleep Medication

10. Pre-Taper For Antidepressants, Antipsychotics, and ADHD Medication

11. How to Taper Off Benzodiazepines, Anti-Convulsants, Anti-Anxiety and Sleep Medication (Slow and Gradual Taper)

12. How to Taper Off Benzodiazepines, Anti-Convulsants, Anti-Anxiety and Sleep Medication (Fast and Gradual Taper)

13. How to Taper Off Antidepressants, Anti-Psychotics and ADHD Medication (Slow and Gradual Taper)

14. How to Taper Off Antidepressants, Anti-Psychotics and ADHD Medication (Fast and Gradual Taper)

15. Once Off All Medication

16. What to Do If You Have Already Started to Taper Off Your Medication or
Just Quit Cold Turkey

17. How to Taper Off Multiple Drugs

18. What You Can Do If You Have Never Taken Psychiatric Drugs

19. Science Behind The Road Back Program

Glossary

References

Additional Testimonials

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Chapter Nineteen

THE SCIENCE BEHIND THE ROAD BACK

INTRODUCTION

The Road Back Program and the Development of the Program:

1. There are basic common denominators of psychotropic drug side effects.
    
2. How our individual DNA affects drug metabolism.
   
3. The effect of psychotropic medication within the Hypothalamus-Pituitary-Adrenal Axis.
    
4. Utilizing DNA clinical trials, test subject trials and psychotropic drug clinical trials to formulate specific nutritional products to eliminate, reduce or avert withdrawal side effects, while not creating drug/supplement interactions.

This research and development complexity has been transformed into an easy to understand, systematic program, which allows an individual to taper off their medication while alleviating a vast percentage of the debilitating side effects of withdrawal.

The sequence of this program and the application of each step is the key to success. Your patient will not even begin to reduce a medication until all or nearly all-existing medication-induced side effects are eliminated. This gives the physician, as well as the patient, prediction, as well as a structured step-by-step standard approach for tapering off psychoactive medication.

Statements of fact: All psychoactive medications metabolize through specific pathways. All psychoactive medications alter the Hypothalamus Pituitary-Adrenal Axis to some degree. To some extent, you can predict the duration before drug-adverse reactions begin with most psychoactive drugs, if the patients’ P450 (CYP) enzymes have been screened.

A poor metabolizer as well as an extensive metabolizer, will eventually reach the same saturation point; the poor metabolizer much faster, of course.

If one were to look at the basic structure of the human body, the chemical structure of psychiatric drugs, and include with this how psychiatric drugs are metabolized, how foods, vitamins, minerals, DNA, amino acids, hormones, glands, proteins, fatty acids, and enzymes work, in relation to psychiatric drugs, you have The Road Back Science.

DNA and Prediction of Drug Adverse Reactions

 
The following charts detail the P450 enzymes used to metabolize the most common antidepressants, anti-psychotics, benzodiazepines, and ADHD stimulant medications. An X in the row denotes that the medication utilizes that specific pathway. Below each chart, you will find other routes of metabolism if applicable.

These medications inhibit metabolism via listed CYP pathways.

These marked medications (*) will also use other routes for metabolism:

Elavil – UGT1A4, UGT1A3, P-gp
Luvox – 2B6, P-gp, intestinal 3A
Paxil – 2B6, P-gp
Prozac – 2B6, P-gp
Tofranil – UGT1A4, UGT1A3, P-gp
Wellbutrin – 2E1, 2A6, 2B6
Zoloft – UGT2B7, UGT1A4, P-gp, 2B6

These marked medications (*) will also use other routes for metabolism:

Clozaril – FMO, UGT1A4, UGT1A3
Geodon – Aldehyde oxidase substrate
Haldol – Glucuronidation, P-gp
Risperdal – P-gp, renal extraction
Seroquel – Glucuronidation, P-gp, intestinal 3A, epoxide by quetiapine
Zyprexa – Glucuronidation, FMO, UGT1A4.

These marked medications (*) will also use other routes for metabolism:

BuSpar – Intestinal 3A
Depakote – UGT2B7, UGT1A6, UGT1A9, UGT2B15, UGT1A4, UGT1A3
Valium – 2B6, UGT2B7, intestinal 3A
Xanax – Hepatic 3A.